PLEASE JOIN US
GIST EDUCATIONAL CONFERENCE AND LUNCHEON
Date: Tuesday, April 21, 2015
Time: 9:30 a.m. to 1:30 p.m., with an optional lab tour to follow
Location: OHSU Center for Health & Healing
3303 SW Bond Ave, Portland, OR 97239
The OHSU Knight Cancer Institute and the GIST Cancer Research Fund
cordially invite you to Oregon Health & Science University on
Tuesday, April 21, for a one-day GIST Educational Conference highlighting
advancements in Gastrointestinal Stromal Tumors (GIST) research.
Brian Druker, M.D.
Christopher Corless, M.D., Ph.D.
Michael Heinrich, M.D.
Caroline Macuiba, LCSW, OSW-C
For questions and to RSVP: 503 552-0681 or firstname.lastname@example.org.
We will mail a detailed agenda and parking information.
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The annual GIST and Sarcoma Cancer Research Conference, organized by the GIST Cancer Research Fund, serves as an invaluable forum for patients and their families to hear about the latest advances in the field from scientists and clinicians at Brigham and Women’s Hospital (BWH) and Dana-Farber Cancer Institute (DFCI).
Last year’s event, which was held in April, was no exception. More than a dozen investigators, physicians, and caregivers at the leading edge of research and care from both BWH and DFCI gathered at the conference to share the latest findings, clinical trial updates, and therapeutic advances with patients, which provide them with the knowledge they need to make informed decisions about their own treatment strategies. Below is a brief synopsis of just a few of the many research highlights from the day’s presentations.
Memorial Sloan-Kettering Cancer Center (MSKCC) is preparing for what it calls “a breakthrough clinical trial” that will test a new drug that uses a MEK inhibitor to target ETV1 in combination with imatinib on a small group of newly diagnosed GIST patients with advanced disease.
We hope to begin recruitment in August, said Dr. William Tap, Section Chief of Sarcoma Oncology at MSKCC. The Phase II trial will be small, with only about 45 participants, and will only have
one site at MSKCC in New York City, he said. That’s because “we just want to show that this approach works,” before recruiting for a larger scale trial, Dr. Tap said. There will be a Phase I portion of the trial to define the Phase II doses of the combination regimen.
The trial is unique because most new GIST clinical trials recruit patients that already have taken imatinib, sunitinib or other drugs and have already developed resistance to those drugs. This trial will try to show that treatment with a combination of imatinib and the MEK inhibitor from the start will be even more effective in combating GIST and will reduce the likelihood of secondary mutations that cause resistance.
Novartis Pharmaceuticals is co-developing the MEK inhibitor, MEK162, with Array Biopharma. MEK162 has been through Phase I trials and recently completed a Phase II trial in NRAS-mutant melanoma.
Dr. Tap said the research that opened the way to this new approach was led by his colleague at MSKCC, Dr. Ping Chi. She was able to show that ETV1, a transcription factor, was essential to the survival of GIST; while it was hard to target ETV1 because it didn’t have molecule-binding pockets that could be blocked by drugs, she found a way around this problem by discovering that MEK inhibitors could do that job.
“MEK inhibitors alone doesn’t seem to be great, but by doing combination therapy with imatinib we get a dramatic response,” Dr. Chi said. ETV1 is a master regulator that is highly expressed in all GISTS.
“Ping’s discovery is one of the major discoveries that we have seen in GIST research since the discovery of KIT,” Dr. Tap said.
ETV1 inhibitor takes lead in combination approach to clinical trials
Posted by Phil Avila – May 20, 2013 – News, Research
In 2010, Dr. Chi published a study she led, “ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours,” in Nature.
GIST Educational Conference – 2013
GIST Cancer Research Fund Presentation
Wednesday April 17, 2013 10:30 am – 2:30 pm
DFCI/BWH – Longwood Inn
(Talk slots are inclusive of ~5-10 minutes discussion time)
10:45-11:00: Arrival, Coffee & Snacks
11:00-11:05: Welcome and Overview of Meeting Goals – Drs. Raut, Butrynski and Fletcher
11:05-11:20: Advances in GIST Surgery – Dr. Chandrajit Raut
1120-1140: Update on Clinical Trials in GIST- Dr. David D’Adamo
11:40-12:00: Treatment Advances from Research on Surgical Specimens – Dr. Jonathan Fletcher
12:00-12:15: Break to pick up Lunch
(Talks and Discussion will continue over lunch)
12:15-12:40: GIST Myth Busters – Amy Pilotte, N.P., Kathleen Polson, N.P., Margaret Loucks, NP, Michelle Lapidus, PA and Christy Harris, Pharm. D.
12:40-1:05: Regorafenib in GIST- Dr. Suzanne George
1:05-1:30: Wild type and SDH Deficient GIST- Dr. Andrew Wagner
1:30-1:45: Identifying Vulnerabilities in Drug Resistant GIST – Dr. Adrian Marino-Enriquez
1:45-2:00: Future Therapeutic Directions for GIST and Conference Wrap-up – Drs. Raut, Butrynski and Fletcher
2:00: GCRF Check Presentation
The GCRF has made available the various updates and technical presentations from recently held sponsored events. These include:
- Advances in GIST Diagnosis and Risk Assessment – Adrián Mariño-Enriquez, MD (video)
Advances in GIST Surgery – Chandrajit P. Raut, MD (video)
Clinical Aspects of GIST – Dr. David DeAdamo (video)
Advances in GIST Therapy #2 (KIT/PDGFRA Downstream Targets) – James E. Butrynski, MD (video)
Advances in “Wildtype” and Pediatric GIST – Katherine A. Janeway, MD (video)
GIST Myth Busters – Amy Pilotte, NP and Kathleen Polson, NP (video)
Identifying Vulnerabilities in Drug Resistant GIST – Jonathan A. Fletcher, MD (video)
High-throughput Methods to Identify Drug Targets – Cesar Serrano Garcia, MD (video)
- Advances in Targeted Therapies for non-GIST Sarcomas – Andrew J. Wagner, MD, PhD (video)
- Future Therapeutic Directions for GIST and Conference Wrap Up (video)
- Interoperative Perspectives of Pediatric GIST – Dr. Mike LaQuaglia (video)
Murine models of imatinib-resistant GIST – Dr. Benedikt Bosbach (video)
Update in Pediatric and Wild-type GIST – Dr. Cristina Antonescu (video)
Phase II study of the Hsp90 Inhibitor BIIB021 in GIST – Dr. Mark Dickson (video)
Update in targeting the immune response in GIST – Dr. Ron DeMatteo (video)
Update on CTLA4 clinical trial – Dr. Richard Carvajal (video)
Advanced interventional radiologic techniques for GIST liver metastases – Dr. Karen Brown (video)