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06. April 2015 · Comments Off on Fox Chase Annual GCRF Luncheon, May 12th · Categories: About GCRF, Doctor Research, Gist Information · Tags:

GIST Invite Final

11. March 2015 · Comments Off on GIST EDUCATIONAL CONFERENCE AND LUNCHEON – April 21st · Categories: Doctor Research, Event Calendar · Tags:

GIST Group Shot

PLEASE JOIN US
GIST EDUCATIONAL CONFERENCE AND LUNCHEON
Date: Tuesday, April 21, 2015
Time: 9:30 a.m. to 1:30 p.m., with an optional lab tour to follow
Location: OHSU Center for Health & Healing
3303 SW Bond Ave, Portland, OR 97239
The OHSU Knight Cancer Institute and the GIST Cancer Research Fund
cordially invite you to Oregon Health & Science University on
Tuesday, April 21, for a one-day GIST Educational Conference highlighting
advancements in Gastrointestinal Stromal Tumors (GIST) research.
Featuring:
Brian Druker, M.D.
Christopher Corless, M.D., Ph.D.
Michael Heinrich, M.D.
Caroline Macuiba, LCSW, OSW-C

For questions and to RSVP: 503 552-0681 or supporttheknight@hsu.edu.
We will mail a detailed agenda and parking information.

Also… ANNUAL DINNER AT THE VINTAGE PLAZA HOTEL
7PM TUES EVENING-APRIL 21 ST
CONTACT –GAIL MANSFIELD IF YOU WOULD LIKE TO ATTEND
or MORE INFORMATION
503-620 4873
Knight Cancer LogoGist Ribbon

10. March 2015 · Comments Off on MSKCC Presentation – April 1st · Categories: Event Calendar, Grants and Research · Tags:

You are cordially invited toMSKC logoA PRESENTATION TO THE GIST CANCER RESEARCH FUND
featuring updates on the most recent research and achievements in clinical treatments at
Memorial Sloan Kettering Cancer Center
Wednesday, April 1, 2015
3:00 p.m.
Rockefeller Research Laboratories, Room 104
Memorial Sloan Kettering Cancer Center
430 East 67th Street
New York City

Please reserve your place by Monday, March 30
Ms. Audrey Williams
william7@mskcc.org or 646.227.3531

or email us or call
tania5kids@aol.com,  T # at Home 845-634-1174

S P E A K E R S:
Benedikt Bosbach, PhD – “Mouse Models Unraveling Therapeutic Avenues in GIST”
Cristina R. Antonescu, MD – “Integrating Genomic Data in Wild Type and Pediatric GIST”
Ping Chi, MD, PhD – “Targeting ETV1 in GIST”
Ronald P. DeMatteo, MD, FACS – “A New Therapeutic Approach in GIST”

Presentations will be followed by a tour of Dr. DeMatteo’s lab in the
Zuckerman Research Center
417 East 68th Street

04. July 2014 · Comments Off on Fox Chase GIST Presentation · Categories: Doctor Research, Event Calendar · Tags:

06. June 2014 · Comments Off on Images from 2014 MSKCC GIST Presentation · Categories: Doctor Research, Event Calendar · Tags: ,

 

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22. May 2013 · Comments Off on MSKCC Prepares for “Breakthrough” Trial · Categories: Doctor Research · Tags:

Memorial Sloan-Kettering Cancer Center (MSKCC) is preparing for what it calls “a breakthrough clinical trial” that will test a new drug that uses a MEK inhibitor to target ETV1 in combination with imatinib on a small group of newly diagnosed GIST patients with advanced disease.

We hope to begin recruitment in August, said Dr. William Tap, Section Chief of Sarcoma Oncology at MSKCC. The Phase II trial will be small, with only about 45 participants, and will only have

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one site at MSKCC in New York City, he said. That’s because “we just want to show that this approach works,” before recruiting for a larger scale trial, Dr. Tap said. There will be a Phase I portion of the trial to define the Phase II doses of the combination regimen.

The trial is unique because most new GIST clinical trials recruit patients that already have taken imatinib, sunitinib or other drugs and have already developed resistance to those drugs. This trial will try to show that treatment with a combination of imatinib and the MEK inhibitor from the start will be even more effective in combating GIST and will reduce the likelihood of secondary mutations that cause resistance.

Novartis Pharmaceuticals is co-developing the MEK inhibitor, MEK162, with Array Biopharma. MEK162 has been through Phase I trials and recently completed a Phase II trial in NRAS-mutant melanoma.

Dr. Tap said the research that opened the way to this new approach was led by his colleague at MSKCC, Dr. Ping Chi. She was able to show that ETV1, a transcription factor, was essential to the survival of GIST; while it was hard to target ETV1 because it didn’t have molecule-binding pockets that could be blocked by drugs, she found a way around this problem by discovering that MEK inhibitors could do that job.

“MEK inhibitors alone doesn’t seem to be great, but by doing combination therapy with imatinib we get a dramatic response,” Dr. Chi said. ETV1 is a master regulator that is highly expressed in all GISTS.

“Ping’s discovery is one of the major discoveries that we have seen in GIST research since the discovery of KIT,” Dr. Tap said.


ETV1 inhibitor takes lead in combination approach to clinical trials
Posted by Phil Avila – May 20, 2013 – News, Research
In 2010, Dr. Chi published a study she led, “ETV1 is a lineage survival factor that cooperates with KIT in gastrointestinal stromal tumours,” in Nature.

28. February 2013 · Comments Off on Fox Chase GCRF Annual Luncheon/Presentation – April 5th, Philadelphia PA · Categories: Event Calendar, Grants and Research · Tags: ,


You are invited to join us for the annual GCRF Luncheon and Presentation – 

When:

Friday, April 5, 2013

12:00 p.m. to 2:00 p.m.

Where: 

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Fox Chase Cancer Center Reimann Auditorium

333 Cottman Avenue

Philadelphia, PA 19111

RSVP to Wanda Ford, 215.728.3163 or by emailing Wanda.Ford@fccc.edu.

03. January 2013 · Comments Off on Agenda Set for April 24th GCRF Presentation at MSKCC · Categories: Event Calendar, Grants and Research · Tags:

04. September 2012 · Comments Off on GIST Cancer Research Fund Supports UPCI Gastrointestinal Cancer Research for 7th Year in a Row · Categories: Grants and Research, News · Tags:

University of Pittsburgh

PITTSBURGH, Aug. 23, 2012 – For the seventh year in a row, researchers from the University of Pittsburgh Cancer Institute (UPCI), partner with UPMC CancerCenter, have received funding from the GIST Cancer Research Fund – a patient-driven organization that funds research on gastrointestinal stromal tumors (GISTs). These tumors occur in the gastrointestinal tract and initially can be successfully treated with the targeted therapy drug Gleevec, but rapidly develop resistance to the treatment.

The $120,000 award supports the research of Anette Duensing, M.D., assistant professor of pathology, University of Pittsburgh School of Medicine. According to Dr. Duensing, GIST research in her laboratory aims to better understand the biology of More »
25. August 2012 · Comments Off on 2012 GIST Conference Presentations Now Online · Categories: Clinical Trials, Doctor Research, Gist Information, Grants and Research, Patient Info, Video · Tags:

The GCRF has made available the various updates and technical presentations from recently held sponsored events.  These include:


Gist and Sarcoma Cancer Research Conference—May 2, 2012 (Brigham & Women's Hospital)

 


Gist Cancer Research Conference—April 4, 2012 (Memorial Sloan-Kettering Cancer Center)

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